TLR9

Across TCGA patient cohorts, TLR9 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR9-associated genes across cancer lineages are MSH2, p62 Lck ligand, and ATM. Each is linked with TLR9 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR9-to-partner and partner-to-TLR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by TLR9-low versus TLR9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR9→partner) and Y-score (partner→TLR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.246	-2.476	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.239	+1.415	.015	.040	3	2
UCEC	ATM →	-0.356	-1.794	.009	.024	3	2
UCEC	Chk2_pT68 →	-0.171	-3.143	.002	<.001	3	2
SKCM	STAT3_pY705 →	-0.256	-2.459	.048	.020	3	2
STAD	Caspase-7-cleavedD198 →	+1.146	+3.000	.002	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MSH2 by TLR9 expression — UCEC

Explore this box plot interactively →