TLR9

Across TCGA cell cohorts, TLR9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,590 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TLR9-associated GO terms across cancer lineages are Negative regulation of macroautophagy, Cilium or flagellum-dependent cell motility, and Regulation of macroautophagy. Each is linked with TLR9 in more than 8 cancer types. Because this analysis shows association rather than direction, both TLR9-to-partner and partner-to-TLR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macroautophagy grouped by TLR9-low versus TLR9-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR9→partner) and Y-score (partner→TLR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of macroautophagy →	+0.062	+0.189	.001	.003	2	9
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.120	-0.088	<.001	.006	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.060	+0.050	<.001	.001	2	8
BLOOD_Lymphoma	Positive regulation of striated muscle contraction →	-0.195	-1.562	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.120	-0.088	<.001	.006	3	7
LUNG_NSCLC_LUSC	Reticulophagy →	+0.060	+0.080	.007	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,590 associations by consensus.

Negative regulation of macroautophagy by TLR9 expression — OVARY

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