TLR9

Across TCGA cell cohorts, TLR9 mutation is significantly associated with the RNA expression of many other genes, with 517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLR9-associated genes across cancer lineages are PRR23D2, GH2, and ATRIP. Each is linked with TLR9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR9-to-partner and partner-to-TLR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23D2 grouped by TLR9-low versus TLR9-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR9→partner) and Y-score (partner→TLR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRR23D2 →	+0.011	+3.518	.006	.008	3	2
BLOOD_Leukemia	GH2 →	+0.014	+3.969	<.001	.009	3	2
LARGE_INTESTINE	ATRIP →	+0.479	+2.451	.002	.009	3	2
BLOOD_Lymphoma	SPATA31A1 →	+0.041	+4.191	.001	.007	3	1
OVARY	ENPP7 →	+0.027	+4.029	<.001	.009	3	1
OVARY	USP17L13 →	+0.010	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 517 associations by consensus.

PRR23D2 by TLR9 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →