TLR8

Across TCGA patient cohorts, TLR8 mutation is significantly associated with the RNA expression of many other genes, with 4,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR8-associated genes across cancer lineages are MIR7854, ZWINT, and EPHB2. Each is linked with TLR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR8-to-partner and partner-to-TLR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7854 grouped by TLR8-low versus TLR8-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR8→partner) and Y-score (partner→TLR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR7854 →	+0.712	+4.969	<.001	.009	3	3
UCEC	ZWINT →	+0.728	+1.628	<.001	<.001	3	3
SKCM	EPHB2 →	-0.480	-2.489	.001	.001	3	3
LIHC	MIR8086 →	+0.206	+4.676	<.001	.004	3	2
SCLC	TAS2R7 →	+0.129	+4.039	<.001	.009	3	2
LIHC	SEPTIN14P19 →	+0.031	+4.305	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,669 associations by consensus.

MIR7854 by TLR8 expression — GBM

Explore this box plot interactively →