TLR8

Across TCGA pan-cancer cohorts, TLR8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TLR8 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TLR8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TLR8 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UVM are the cancer types where TLR8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.420	0.255	<.001	127	view →
HNSC	DFS	Median	III,IV	0.641	0.483	<.001	102	view →
UVM	OS	Tertile	All	0.446	0.801	.002	67	view →
LGG	OS	Tertile	All	0.355	0.591	<.001	46	view →
CESC	DFS	Quartile	II,III,IV	0.903	0.606	.001	44	view →
KIRC	DFS	Median	IV	0.738	0.444	.015	33	view →
LUSC	DFS	Median	II,III,IV	0.584	0.887	.002	29	view →
LUAD	DFS	Quartile	All	0.853	0.721	.002	25	view →
UCS	DFS	Tertile	IV	0.942	0.336	.017	24	view →
LAML	DFS	Median	All	0.434	0.694	.013	24	view →
GBM	DFS	Quartile	All	0.202	0.359	.012	15	view →
THYM	OS	Median	II,III,IV	0.920	1.000	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TLR8–SKCM (OS)

Open the SKCM breakdown →