TLR8

Across TCGA patient cohorts, TLR8 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR8-associated genes across cancer lineages are p21, PCNA, and VHL. Each is linked with TLR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR8-to-partner and partner-to-TLR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by TLR8-low versus TLR8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR8→partner) and Y-score (partner→TLR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p21 →	-0.494	-1.497	<.001	.014	3	3
UCEC	PCNA →	+0.155	+1.347	.012	.006	3	3
UCEC	VHL →	-0.719	-1.353	<.001	.013	3	3
UCEC	eIF4E →	+0.179	+4.013	.003	<.001	3	2
UCEC	IGFBP2 →	-0.433	-0.999	.020	.042	3	2
UCEC	STAT3_pY705 →	-0.293	-1.247	<.001	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p21 by TLR8 expression — SKCM

Explore this box plot interactively →