TLR8

Across TCGA cell cohorts, TLR8 RNA expression is significantly associated with the go_rna of many other GO terms, with 619 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLR8-associated GO terms across cancer lineages are Positive regulation of toll-like receptor 9 signaling pathway, Protein-lipid complex organization, and Response to rapamycin. Each is linked with TLR8 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLR8-to-partner and partner-to-TLR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of toll-like receptor 9 signaling pathway grouped by TLR8-low versus TLR8-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR8→partner) and Y-score (partner→TLR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of toll-like receptor 9 signaling pathway →	+0.093	+0.365	<.001	.005	3	4
PANCREAS	Protein-lipid complex organization →	+0.069	+0.006	.004	.007	3	3
BLOOD_Leukemia	Response to rapamycin →	+0.047	+0.387	.003	.003	3	3
BLOOD_Leukemia	Protein deneddylation →	+0.066	+0.646	<.001	.005	3	3
BLOOD_Leukemia	Indole-containing compound catabolic process →	-0.185	-0.584	<.001	.002	3	3
BLOOD_Leukemia	Response to epidermal growth factor →	+0.044	+0.755	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 619 associations by consensus.

Positive regulation of toll-like receptor 9 signaling pathway by TLR8 expression — BLOOD_Leukemia

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