TLR8

Across TCGA cell cohorts, TLR8 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TLR8-associated genes across cancer lineages are BPIFB6, OR10A5, and OR11G2. Each is linked with TLR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR8-to-partner and partner-to-TLR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by TLR8-low versus TLR8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR8→partner) and Y-score (partner→TLR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	2
BREAST	OR10A5 →	+0.028	+5.169	<.001	.005	3	1
BREAST	OR11G2 →	+0.013	+5.169	<.001	.005	3	1
BREAST	IFNA4 →	+0.018	+5.169	<.001	.005	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.631	+3.772	<.001	.003	3	1
LARGE_INTESTINE	TREML1 →	+0.079	+3.658	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

BPIFB6 by TLR8 expression — BLOOD_Leukemia

Explore this box plot interactively →