TLR8-AS1

Across TCGA patient cohorts, TLR8-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,937 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible TLR8-AS1-associated GO terms across cancer lineages are Positive regulation of tumor necrosis factor superfamily cytokine production, Myeloid leukocyte activation, and Positive regulation of monocyte chemotactic protein-1 production. Each is linked with TLR8-AS1 in more than 13 cancer types. Because this analysis shows association rather than direction, both TLR8-AS1-to-partner and partner-to-TLR8-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of tumor necrosis factor superfamily cytokine production grouped by TLR8-AS1-low versus TLR8-AS1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR8-AS1→partner) and Y-score (partner→TLR8-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Positive regulation of tumor necrosis factor superfamily cytokine production →	+0.055	+0.360	<.001	<.001	3	13
STAD	Myeloid leukocyte activation →	+0.056	+0.069	<.001	.002	3	13
LAML	Positive regulation of monocyte chemotactic protein-1 production →	+0.087	+0.283	<.001	<.001	3	12
STAD	Regulation of adaptive immune response →	+0.059	+0.074	<.001	<.001	2	13
STAD	Regulation of mast cell activation →	+0.047	+0.080	<.001	<.001	3	12
STAD	Phagocytosis →	+0.065	+0.081	<.001	<.001	1	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,937 associations by consensus.

Positive regulation of tumor necrosis factor superfamily cytokine production by TLR8-AS1 expression — LAML

Explore this box plot interactively →