TLR8-AS1

Across TCGA pan-cancer cohorts, TLR8-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TLR8-AS1 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TLR8-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TLR8-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

STAD, LUAD, and ACC are the cancer types where TLR8-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	All	0.410	0.601	<.001	93	view →
LUAD	DFS	Tertile	All	0.733	0.572	<.001	82	view →
ACC	DFS	Tertile	All	0.237	0.655	.002	57	view →
GBM	OS	Tertile	All	0.299	0.457	<.001	36	view →
OV	OS	Median	II,III,IV	0.878	0.802	.005	34	view →
LUSC	DFS	Tertile	All	0.676	0.807	<.001	34	view →
KIRC	DFS	Quartile	All	0.688	0.838	<.001	33	view →
LAML	DFS	Tertile	All	0.282	0.579	.003	32	view →
ESCA	DFS	Tertile	II,III,IV	0.296	1.000	.008	27	view →
LGG	DFS	Tertile	All	0.720	0.857	<.001	27	view →
UCEC	DFS	Median	All	0.504	0.734	.015	22	view →
SKCM	OS	Tertile	All	0.923	0.846	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TLR8-AS1–STAD (DFS)

Open the STAD breakdown →