Across TCGA patient cohorts, TLR7 mutation is significantly associated with the RNA expression of many other genes, with 4,306 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR7-associated genes across cancer lineages are PGAM5, SSRP1, and SMARCB1. Each is linked with TLR7 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLR7-to-partner and partner-to-TLR7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR7→partner) and Y-score (partner→TLR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM5 →	+0.531	+2.129	<.001	<.001	3	4
SKCM	SSRP1 →	+0.474	+2.334	<.001	<.001	3	4
COAD	SMARCB1 →	+0.346	+2.713	.007	.003	3	4
COAD	ENO1 →	+0.610	+3.361	<.001	.004	3	4
COAD	RCC1 →	+0.653	+3.861	<.001	<.001	3	4
UCEC	SMARCE1P2 →	+0.110	+1.506	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,306 associations by consensus.

Exploration

TLR7 survival (RNA) · tumor vs normal (RNA) · all TLR7 data types