Across TCGA patient cohorts, TLR5 protein abundance is significantly associated with the RNA expression of many other genes, with 3,331 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TLR5-associated genes across cancer lineages are MCM4, POU3F4, and CFTR. Each is linked with TLR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR5-to-partner and partner-to-TLR5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR5→partner) and Y-score (partner→TLR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM4 →	-1.262	-1.049	.002	.004	3	3
GBM	POU3F4 →	-2.671	-1.172	<.001	<.001	3	2
OV	CFTR →	+3.278	+0.917	.001	.005	3	2
UCEC	ZNF175 →	-0.782	-0.497	.001	.006	3	2
GBM	KHDRBS1 →	-0.354	-0.712	.002	.002	3	2
CCRCC	PSPN →	-0.560	-1.429	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,331 associations by consensus.

Exploration

TLR5 survival (RNA) · tumor vs normal (RNA) · all TLR5 data types