TLR10

Across TCGA patient cohorts, TLR10 mutation is significantly associated with the RNA expression of many other genes, with 2,884 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR10-associated genes across cancer lineages are HMGN1P20, IFNA10, and ATG3. Each is linked with TLR10 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR10-to-partner and partner-to-TLR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN1P20 grouped by TLR10-low versus TLR10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR10→partner) and Y-score (partner→TLR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HMGN1P20 →	+0.185	+3.910	<.001	.006	3	3
GBM	IFNA10 →	+0.087	+5.352	<.001	.005	3	3
UCEC	ATG3 →	+0.365	+3.031	.001	<.001	3	3
SKCM	BOLA2-SMG1P6 →	+0.515	+2.610	<.001	.005	3	3
GBM	MIR7975 →	+0.821	+5.857	<.001	.002	3	2
SKCM	CAP1P1 →	+0.496	+2.739	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,884 associations by consensus.

HMGN1P20 by TLR10 expression — COAD

Explore this box plot interactively →