TLR10

Across TCGA pan-cancer cohorts, TLR10 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TLR10 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TLR10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TLR10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where TLR10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.745	0.624	<.001	138	view →
SKCM	OS	Median	All	0.851	0.706	<.001	136	view →
LUAD	DFS	Median	All	0.737	0.597	<.001	97	view →
CESC	DFS	Quartile	All	0.847	0.627	<.001	68	view →
BRCA	OS	Quartile	All	0.971	0.934	<.001	62	view →
LGG	OS	Tertile	All	0.366	0.536	<.001	39	view →
SARC	OS	Median	All	0.609	0.420	<.001	38	view →
UCEC	OS	Quartile	All	0.925	0.840	.010	30	view →
UCS	DFS	Tertile	IV	0.956	0.422	.024	24	view →
READ	OS	Median	IV	1.000	0.572	.008	17	view →
LUSC	DFS	Median	III,IV	0.639	0.360	.004	17	view →
COAD	DFS	Median	All	0.745	0.638	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TLR10–HNSC (DFS)

Open the HNSC breakdown →