TLR10

Across TCGA cell cohorts, TLR10 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLR10-associated genes across cancer lineages are MBD3L5, POM121L12, and SAGE1. Each is linked with TLR10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR10-to-partner and partner-to-TLR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L5 grouped by TLR10-low versus TLR10-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR10→partner) and Y-score (partner→TLR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MBD3L5 →	+0.024	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.022	+5.266	<.001	.001	3	1
LARGE_INTESTINE	SAGE1 →	+0.057	+3.906	.008	.002	3	1
LARGE_INTESTINE	TECRL →	+0.011	+3.240	<.001	.004	3	1
LARGE_INTESTINE	IQCF6 →	+0.188	+2.882	<.001	.005	3	1
LUNG_SCLC	OR5T2 →	+0.020	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MBD3L5 by TLR10 expression — SKIN

Explore this box plot interactively →