TLNRD1

Across TCGA cell cohorts, TLNRD1 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLNRD1-associated genes across cancer lineages are CCER1, KRTAP5-11, and DEFB131B. Each is linked with TLNRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLNRD1-to-partner and partner-to-TLNRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCER1 grouped by TLNRD1-low versus TLNRD1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLNRD1→partner) and Y-score (partner→TLNRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCER1 →	+0.016	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.055	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DEFB131B →	+0.181	+4.887	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.365	+3.502	<.001	.001	3	1
LARGE_INTESTINE	CA2 →	+2.314	+3.502	<.001	.001	3	1
LARGE_INTESTINE	RASA4 →	-0.933	-3.416	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

CCER1 by TLNRD1 expression — CNS

Explore this box plot interactively →