TLN2

Across TCGA pan-cancer cohorts, TLN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TLN2 data layer compared with 24 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TLN2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TLN2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where TLN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.554	0.802	.017	18	view →
PDAC	DFS	Quartile	III,IV	0.227	0.907	.002	13	view →
UCEC	OS	Quartile	II,III,IV	0.544	1.000	.029	8	view →
LUAD	DFS	Median	II,III,IV	0.749	0.957	.001	3	view →
CCRCC	DFS	Median	III,IV	1.000	0.451	.032	2	view →
HNSC	DFS	Median	III,IV	0.856	0.712	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TLN2–LSCC (DFS)

Open the LSCC breakdown →