TLN2

Across TCGA pan-cancer cohorts, TLN2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TLN2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TLN2 RNA is repressed in tumor relative to normal tissue. In most cancer types TLN2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and THCA are the cancer types where TLN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TLN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−1.793	<.001	11	view →
KICH	Female	II,III,IV	−3.631	<.001	10	view →
THCA	Male	III,IV	−1.391	<.001	10	view →
COAD	Female	All	−0.806	<.001	8	view →
HNSC	All	III,IV	+0.730	<.001	8	view →
BLCA	Male	All	−1.130	<.001	7	view →
KIRC	Male	II,III,IV	−0.729	<.001	7	view →
BRCA	All	III,IV	−1.551	<.001	6	view →
LUSC	All	All	+0.559	<.001	5	view →
STAD	Male	II,III,IV	+1.068	.003	3	view →
CHOL	All	All	+0.994	<.001	2	view →
LIHC	Male	All	+0.532	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TLN2–KIRP

Open the KIRP breakdown →