TLN2

Across TCGA patient cohorts, TLN2 mutation is significantly associated with the RNA expression of many other genes, with 9,051 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLN2-associated genes across cancer lineages are ARHGAP11A, DTL, and CENPU. Each is linked with TLN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TLN2-to-partner and partner-to-TLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP11A grouped by TLN2-low versus TLN2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLN2→partner) and Y-score (partner→TLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGAP11A →	+0.933	+3.608	<.001	.001	3	6
STAD	DTL →	+0.786	+2.297	<.001	<.001	3	6
LUAD	CENPU →	+1.003	+3.735	<.001	<.001	3	6
UCEC	UHRF1 →	+0.815	+2.040	<.001	<.001	3	6
STAD	CDCA2 →	+0.879	+3.919	<.001	<.001	2	6
LUAD	PRC1 →	+1.018	+3.087	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,051 associations by consensus.

ARHGAP11A by TLN2 expression — LUAD

Explore this box plot interactively →