TLN2

Across TCGA patient cohorts, TLN2 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLN2-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and c-Met_pY1235. Each is linked with TLN2 in more than 6 cancer types. Because this analysis shows association rather than direction, both TLN2-to-partner and partner-to-TLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TLN2-low versus TLN2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLN2→partner) and Y-score (partner→TLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.738	+3.321	.006	.008	3	7
COAD	ATM →	-0.650	-2.459	<.001	.018	3	6
BLCA	c-Met_pY1235 →	+0.091	+2.115	.013	.018	3	6
LUAD	ASNS →	+0.602	+3.169	.003	.018	3	5
LUAD	Caveolin-1 →	-0.665	-3.000	.038	.035	3	5
STAD	Cyclin-B1 →	+0.661	+3.906	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Caspase-7-cleavedD198 by TLN2 expression — STAD

Explore this box plot interactively →