TLN2

Across TCGA cell cohorts, TLN2 mutation is significantly associated with the RNA expression of many other genes, with 1,507 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLN2-associated genes across cancer lineages are CLPP, LINC02693, and HSD17B6. Each is linked with TLN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLN2-to-partner and partner-to-TLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPP grouped by TLN2-low versus TLN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLN2→partner) and Y-score (partner→TLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLPP →	+0.376	+2.145	.007	.006	3	3
BLOOD_Leukemia	LINC02693 →	+1.094	+2.837	.001	<.001	3	3
LARGE_INTESTINE	HSD17B6 →	+0.807	+1.714	<.001	.006	3	3
LARGE_INTESTINE	ELP5 →	+0.591	+3.584	.001	<.001	3	3
LARGE_INTESTINE	UBR2 →	+0.558	+3.404	<.001	<.001	3	3
LARGE_INTESTINE	ACTR6 →	+0.744	+2.631	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,507 associations by consensus.

CLPP by TLN2 expression — BLOOD_Leukemia

Explore this box plot interactively →