TLL2

Across TCGA patient cohorts, TLL2 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLL2-associated genes across cancer lineages are FoxM1, VHL, and 4E-BP1_pS65. Each is linked with TLL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLL2-to-partner and partner-to-TLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TLL2-low versus TLL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLL2→partner) and Y-score (partner→TLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.181	+1.874	.023	.049	3	2
UCEC	VHL →	-0.849	-1.736	<.001	.006	3	2
SKCM	4E-BP1_pS65 →	+0.233	+2.597	.002	.005	3	2
UCEC	Cyclin-B1 →	+0.577	+1.938	.001	.001	3	2
SKCM	Cyclin-D1 →	-0.216	-2.309	.012	.033	3	2
COAD	Caspase-7-cleavedD198 →	+1.367	+3.330	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

FoxM1 by TLL2 expression — SKCM

Explore this box plot interactively →