TLL2

Across TCGA cell cohorts, TLL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,266 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLL2-associated GO terms across cancer lineages are Cellular response to nutrient levels, Mitotic cytokinesis, and Telomerase holoenzyme complex assembly. Each is linked with TLL2 in more than 6 cancer types. Because this analysis shows association rather than direction, both TLL2-to-partner and partner-to-TLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to nutrient levels grouped by TLL2-low versus TLL2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLL2→partner) and Y-score (partner→TLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Cellular response to nutrient levels →	+0.022	+0.503	.005	<.001	3	7
BREAST	Mitotic cytokinesis →	+0.075	+0.127	<.001	.006	3	6
CNS	Telomerase holoenzyme complex assembly →	+0.044	+0.780	<.001	.003	3	6
BLOOD_Lymphoma	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.049	+0.542	<.001	<.001	3	6
BLOOD_Lymphoma	mRNA splicing, via spliceosome →	+0.049	+0.542	<.001	<.001	3	6
LARGE_INTESTINE	Response to starvation →	+0.033	+0.292	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,266 associations by consensus.

Cellular response to nutrient levels by TLL2 expression — BLOOD_Lymphoma

Explore this box plot interactively →