Across TCGA patient cohorts, TLK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,066 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TLK1-associated proteins across cancer lineages are SSB, PPIG, and PRKRA. Each is linked with TLK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TLK1-to-partner and partner-to-TLK1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TLK1→partner) and Y-score (partner→TLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SSB →	+0.309	+0.606	<.001	<.001	3	6
LSCC	PPIG →	+0.254	+0.473	<.001	<.001	3	5
OV	PRKRA →	+0.281	+0.427	.004	<.001	3	5
PDAC	SRRT_T544 →	+0.945	+0.322	<.001	<.001	3	5
LSCC	SAE1 →	+0.314	+0.572	<.001	<.001	3	5
LSCC	C1orf35 →	+0.371	+0.438	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,066 associations by consensus.

Exploration

TLK1 survival (RNA) · tumor vs normal (RNA) · all TLK1 data types