TLE6

Across TCGA patient cohorts, TLE6 mutation is significantly associated with the RNA expression of many other genes, with 2,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE6-associated genes across cancer lineages are ADAMTS4, UHRF1, and CHAF1A. Each is linked with TLE6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLE6-to-partner and partner-to-TLE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS4 grouped by TLE6-low versus TLE6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE6→partner) and Y-score (partner→TLE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ADAMTS4 →	+0.939	+2.006	.007	.005	3	3
UCEC	UHRF1 →	+0.870	+1.818	<.001	.002	3	3
UCEC	CHAF1A →	+0.764	+3.021	<.001	<.001	3	3
UCEC	GPR3 →	+0.454	+2.137	.009	.001	3	3
UCEC	PRC1 →	+0.748	+2.446	<.001	.001	3	3
UCEC	VPS18 →	+0.576	+3.928	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

ADAMTS4 by TLE6 expression — SKCM

Explore this box plot interactively →