TLE6

Across TCGA pan-cancer cohorts, TLE6 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TLE6 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TLE6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TLE6 expression acts as an unfavorable survival marker, although some lineages such as THYM and MESO show a favorable association.

KIRP, ACC, and COAD are the cancer types where TLE6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.414	0.819	<.001	88	view →
ACC	DFS	Tertile	All	0.385	0.760	.001	81	view →
COAD	DFS	Median	All	0.421	0.622	<.001	75	view →
UCS	OS	Quartile	III,IV	0.190	0.731	.003	42	view →
CESC	DFS	Quartile	All	0.737	0.902	<.001	24	view →
PRAD	DFS	Tertile	All	0.712	0.905	<.001	20	view →
LUSC	DFS	Tertile	II,III,IV	0.307	0.524	.004	17	view →
THYM	OS	Median	All	1.000	0.709	<.001	16	view →
MESO	OS	Median	All	0.354	0.218	.026	15	view →
LAML	DFS	Median	All	0.409	0.733	<.001	14	view →
KIRC	DFS	Quartile	All	0.509	0.676	.013	14	view →
SKCM	DFS	Tertile	II,III,IV	0.736	0.641	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TLE6–KIRP (DFS)

Open the KIRP breakdown →