TLE6

Across TCGA cell cohorts, TLE6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TLE6-associated genes across cancer lineages are CCL13, MS4A6E, and OR1L6. Each is linked with TLE6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE6-to-partner and partner-to-TLE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL13 grouped by TLE6-low versus TLE6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE6→partner) and Y-score (partner→TLE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCL13 →	+0.505	+4.781	<.001	.003	3	2
BONE	MS4A6E →	+0.040	+5.169	<.001	.004	3	1
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	OR6C4 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BONE	CXorf51A →	+0.090	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CCL13 by TLE6 expression — BREAST

Explore this box plot interactively →