TLE6

Across TCGA cell cohorts, TLE6 mutation is significantly associated with the mutation status of many other genes, with 3,878 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLE6-associated genes across cancer lineages are CABIN1, PTPRN2, and ATP2B3. Each is linked with TLE6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLE6-to-partner and partner-to-TLE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABIN1 grouped by TLE6-low versus TLE6-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE6→partner) and Y-score (partner→TLE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CABIN1 →	+5.000	+4.437	.007	.007	1	4
OVARY	PTPRN2 →	+4.415	+4.977	.007	.007	1	4
OVARY	ATP2B3 →	+4.415	+4.977	.007	.007	1	4
BLOOD_Leukemia	FREM1 →	+2.243	+2.959	.008	.008	1	4
LARGE_INTESTINE	ZMIZ1 →	+1.777	+2.963	.004	.004	1	4
LARGE_INTESTINE	MYH11 →	+2.263	+3.392	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,878 associations by consensus.

CABIN1 by TLE6 expression — BONE

Explore this box plot interactively →