TLE3

Across TCGA cell cohorts, TLE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,483 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TLE3-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Negative regulation of DNA-templated transcription, elongation, and Negative regulation of RNA splicing. Each is linked with TLE3 in more than 14 cancer types. Because this analysis shows association rather than direction, both TLE3-to-partner and partner-to-TLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by TLE3-low versus TLE3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE3→partner) and Y-score (partner→TLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.188	+1.762	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of DNA-templated transcription, elongation →	+0.130	+1.182	.001	.004	3	15
BONE	Negative regulation of RNA splicing →	+0.094	+0.974	<.001	<.001	3	15
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.143	+1.897	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of transcription elongation by RNA polymerase II →	+0.134	+1.430	<.001	<.001	3	14
BONE	Negative regulation of mRNA processing →	+0.141	+1.898	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,483 associations by consensus.

Negative regulation of chromosome condensation by TLE3 expression — SOFT_TISSUE

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