TLE3

Across TCGA cell cohorts, TLE3 mutation is significantly associated with the RNA expression of many other genes, with 535 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLE3-associated genes across cancer lineages are C10orf53, OPN4, and TMEM210. Each is linked with TLE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE3-to-partner and partner-to-TLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by TLE3-low versus TLE3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE3→partner) and Y-score (partner→TLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.007	+2.462	.003	.004	3	2
SKIN	OPN4 →	+0.027	+4.273	.008	.006	3	1
SKIN	TMEM210 →	+0.036	+4.415	<.001	.007	3	1
SKIN	DPPA5 →	+0.041	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	LYVE1 →	+0.028	+3.843	.002	.007	3	1
BLOOD_Lymphoma	PRY2 →	+0.029	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 535 associations by consensus.

C10orf53 by TLE3 expression — LARGE_INTESTINE

Explore this box plot interactively →