TLE2

Across TCGA patient cohorts, TLE2 mutation is significantly associated with the RNA expression of many other genes, with 2,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE2-associated genes across cancer lineages are RNU6-177P, RNU6-625P, and RNU6-75P. Each is linked with TLE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLE2-to-partner and partner-to-TLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-177P grouped by TLE2-low versus TLE2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE2→partner) and Y-score (partner→TLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-177P →	+0.129	+2.864	<.001	.002	3	3
CESC	RNU6-625P →	+0.154	+4.020	<.001	.009	3	2
CESC	RNU6-75P →	+0.365	+4.516	<.001	.004	3	2
CESC	RNU6-3P →	+0.462	+3.721	.001	.004	3	2
CESC	MIR649 →	+0.297	+3.536	.002	.002	3	2
SKCM	NDFIP2 →	+0.657	+3.106	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,428 associations by consensus.

RNU6-177P by TLE2 expression — SKCM

Explore this box plot interactively →