Across TCGA patient cohorts, TLE1 mutation is significantly associated with the RNA expression of many other genes, with 2,377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE1-associated genes across cancer lineages are GFM2, TAF9, and RBBP8. Each is linked with TLE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLE1-to-partner and partner-to-TLE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE1→partner) and Y-score (partner→TLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GFM2 →	+0.537	+2.672	<.001	<.001	3	3
UCEC	TAF9 →	+0.683	+2.722	<.001	<.001	3	3
UCEC	RBBP8 →	+0.521	+1.485	.001	.003	3	3
UCEC	CENPE →	+0.415	+1.679	.008	.006	3	3
UCEC	UAP1L1 →	+0.529	+2.201	<.001	<.001	3	3
UCEC	CYCSP44 →	+0.130	+2.124	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,377 associations by consensus.

Exploration

TLE1 survival (RNA) · tumor vs normal (RNA) · all TLE1 data types