TLCD5

Across TCGA patient cohorts, TLCD5 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLCD5-associated genes across cancer lineages are Raptor, VHL, and Beclin. Each is linked with TLCD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD5-to-partner and partner-to-TLCD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Raptor grouped by TLCD5-low versus TLCD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD5→partner) and Y-score (partner→TLCD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Raptor →	-0.200	-3.169	.016	.020	3	1
UCEC	VHL →	-1.124	-3.000	.002	.036	3	1
UCEC	Beclin →	+0.154	+3.169	.003	.020	3	1
UCEC	Caspase-8 →	-0.295	-2.973	.033	.035	3	1
UCEC	Notch1 →	+0.203	+3.169	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Raptor by TLCD5 expression — UCEC

Explore this box plot interactively →