TLCD4-RWDD3

Across TCGA pan-cancer cohorts, TLCD4-RWDD3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TLCD4-RWDD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TLCD4-RWDD3 RNA is repressed in tumor relative to normal tissue. In most cancer types TLCD4-RWDD3 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, BLCA, and HNSC are the cancer types where TLCD4-RWDD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TLCD4-RWDD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.571	<.001	6	view →
BLCA	Female	All	+0.437	.003	6	view →
HNSC	Male	III,IV	+0.172	.008	4	view →
KIRP	All	IV	+0.492	.008	2	view →
COAD	Female	All	−0.232	.037	2	view →
STAD	All	II,III,IV	+0.226	.025	2	view →
STAD	Male	IV	−0.175	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 6 lineages.

TLCD4-RWDD3–KICH

Open the KICH breakdown →