TLCD3B

Across TCGA patient cohorts, TLCD3B mutation is significantly associated with the immune_cell of many other genes, with 16 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TLCD3B-associated genes across cancer lineages are Osteoblast, CD8+ T-cells, and CD8+ Tcm. Each is linked with TLCD3B in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD3B-to-partner and partner-to-TLCD3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Osteoblast grouped by TLCD3B-low versus TLCD3B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD3B→partner) and Y-score (partner→TLCD3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Osteoblast →	+0.033	+3.859	.020	.004	3	2
COAD	CD8+ T-cells →	+0.019	+5.142	.001	.041	3	1
COAD	CD8+ Tcm →	+0.029	+4.917	.001	.048	3	1
COAD	Monocytes →	+0.023	+5.734	<.001	.027	3	1
COAD	Preadipocytes →	+0.107	+4.169	<.001	.027	3	1
COAD	Tregs →	+0.081	+5.409	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Osteoblast by TLCD3B expression — LUSC

Explore this box plot interactively →