TLCD3B

Across TCGA cell cohorts, TLCD3B mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLCD3B-associated genes across cancer lineages are RBMY1B, RBMY1D, and GML. Each is linked with TLCD3B in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD3B-to-partner and partner-to-TLCD3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1B grouped by TLCD3B-low versus TLCD3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD3B→partner) and Y-score (partner→TLCD3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RBMY1B →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	RBMY1D →	+0.004	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CALHM4 →	+0.019	+5.269	.004	<.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	OR1G1 →	+0.083	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

RBMY1B by TLCD3B expression — LARGE_INTESTINE

Explore this box plot interactively →