TKTL1

Across TCGA patient cohorts, TKTL1 mutation is significantly associated with the RNA expression of many other genes, with 4,324 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKTL1-associated genes across cancer lineages are RNU1-57P, CAPZA1P3, and TRAIP. Each is linked with TKTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TKTL1-to-partner and partner-to-TKTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by TKTL1-low versus TKTL1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL1→partner) and Y-score (partner→TKTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU1-57P →	+0.393	+3.289	<.001	.007	3	3
LUAD	CAPZA1P3 →	+0.088	+4.293	<.001	.008	3	3
UCEC	TRAIP →	+0.480	+2.346	.001	.003	3	3
UCEC	ERCC6L →	+0.678	+2.058	<.001	<.001	3	3
UCEC	TRAJ57 →	+0.399	+2.248	<.001	<.001	3	3
UCEC	CENPU →	+0.823	+2.410	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,324 associations by consensus.

RNU1-57P by TKTL1 expression — STAD

Explore this box plot interactively →