TKTL1

Across TCGA cell cohorts, TKTL1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TKTL1-associated genes across cancer lineages are APOC4, IL2, and BPIFA3. Each is linked with TKTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TKTL1-to-partner and partner-to-TKTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOC4 grouped by TKTL1-low versus TKTL1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL1→partner) and Y-score (partner→TKTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	APOC4 →	+0.071	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	IL2 →	+0.036	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	BPIFA3 →	+0.036	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CNTN6 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	OR7G2 →	+0.063	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	C10orf71 →	+0.013	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

APOC4 by TKTL1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →