TKFC

Across TCGA patient cohorts, TKFC mutation is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKFC-associated genes across cancer lineages are RNU6-1213P, MIR5189, and MIR606. Each is linked with TKFC in more than 2 cancer types. Because this analysis shows association rather than direction, both TKFC-to-partner and partner-to-TKFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by TKFC-low versus TKFC-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKFC→partner) and Y-score (partner→TKFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1213P →	+0.508	+7.930	<.001	.008	3	3
BRCA	MIR5189 →	+0.611	+5.070	<.001	.008	3	2
BRCA	MIR606 →	+0.652	+5.473	<.001	.005	3	2
SKCM	RPL22P13 →	+0.174	+2.893	<.001	.006	3	2
COAD	RNA5SP362 →	+0.362	+5.734	<.001	<.001	3	2
BRCA	RNU6-331P →	+0.623	+5.020	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

RNU6-1213P by TKFC expression — LUAD

Explore this box plot interactively →