TKFC

Across TCGA cell cohorts, TKFC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,324 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TKFC-associated GO terms across cancer lineages are Negative regulation of MDA-5 signaling pathway, Glyceraldehyde-3-phosphate metabolic process, and Fructose catabolic process. Each is linked with TKFC in more than 16 cancer types. Because this analysis shows association rather than direction, both TKFC-to-partner and partner-to-TKFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of MDA-5 signaling pathway grouped by TKFC-low versus TKFC-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TKFC→partner) and Y-score (partner→TKFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of MDA-5 signaling pathway →	+0.187	+0.714	.002	.001	3	17
LUNG_NSCLC_LUSC	Glyceraldehyde-3-phosphate metabolic process →	+0.171	+0.907	.001	.003	3	16
LIVER	Fructose catabolic process →	+0.381	+1.620	<.001	.004	3	15
LIVER	Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate →	+0.381	+1.620	<.001	.004	3	15
LUNG_NSCLC_LUSC	Glycerol catabolic process →	+0.170	+1.065	.009	<.001	2	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.129	+1.033	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,324 associations by consensus.

Negative regulation of MDA-5 signaling pathway by TKFC expression — LUNG_SCLC

Explore this box plot interactively →