TKFC

Across TCGA cell cohorts, TKFC mutation is significantly associated with the RNA expression of many other genes, with 339 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TKFC-associated genes across cancer lineages are RHOXF1, SAXO1, and SFT2D3. Each is linked with TKFC in more than 1 cancer types. Because this analysis shows association rather than direction, both TKFC-to-partner and partner-to-TKFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHOXF1 grouped by TKFC-low versus TKFC-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKFC→partner) and Y-score (partner→TKFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RHOXF1 →	+0.145	+3.643	<.001	.007	3	1
URINARY_TRACT	SAXO1 →	+0.079	+3.584	<.001	.008	3	1
URINARY_TRACT	SFT2D3 →	+0.611	+3.807	.002	.005	3	1
URINARY_TRACT	ZNF648 →	+0.184	+4.115	<.001	.001	3	1
URINARY_TRACT	C3orf22 →	+0.013	+3.584	<.001	.005	3	1
URINARY_TRACT	HTR3D →	+0.026	+4.044	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 339 associations by consensus.

RHOXF1 by TKFC expression — URINARY_TRACT

Explore this box plot interactively →