TK2

Across TCGA patient cohorts, TK2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,944 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TK2-associated genes across cancer lineages are NDC1, CDC6, and CDKN3. Each is linked with TK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both TK2-to-partner and partner-to-TK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TK2 versus NDC1 in LSCC, with a Pearson correlation of -0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TK2→partner) and Y-score (partner→TK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NDC1 →	-0.738	-0.407	<.001	<.001	3	8
UCEC	CDC6 →	-1.020	-0.453	<.001	<.001	3	8
OV	CDKN3 →	-1.493	-0.371	<.001	.001	3	7
OV	CENPI →	-0.951	-0.416	<.001	.003	3	7
OV	NCAPG →	-1.389	-0.475	<.001	<.001	3	7
BRCA	RAD51AP1 →	-0.970	-0.359	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,944 associations by consensus.

TK2 vs NDC1 — LSCC

Explore this scatter interactively →