TK2

Across TCGA pan-cancer cohorts, TK2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TK2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TK2 RNA is repressed in tumor relative to normal tissue. In most cancer types TK2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and UCEC are the cancer types where TK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.495	<.001	8	view →
LUSC	Male	All	−0.961	<.001	7	view →
UCEC	All	All	−1.116	<.001	6	view →
BRCA	All	All	−0.931	<.001	6	view →
STAD	Male	All	+0.632	.003	4	view →
KIRP	All	All	+0.491	.001	3	view →
THCA	All	All	+0.199	.006	2	view →
COAD	All	II,III,IV	+0.196	.035	2	view →
LUAD	All	All	−0.198	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TK2–KICH

Open the KICH breakdown →