TK2

Across TCGA patient cohorts, TK2 mutation is significantly associated with the RNA expression of many other genes, with 1,952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TK2-associated genes across cancer lineages are MIR4648, LIN7C, and PTPRJ. Each is linked with TK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TK2-to-partner and partner-to-TK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4648 grouped by TK2-low versus TK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TK2→partner) and Y-score (partner→TK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4648 →	+0.460	+4.765	.001	.003	3	2
UCEC	LIN7C →	+0.560	+2.243	.006	.006	3	1
UCEC	PTPRJ →	+0.722	+3.483	.002	.002	3	1
UCEC	COX15 →	+0.561	+3.592	<.001	.001	3	1
UCEC	MTA2 →	+0.457	+3.641	.001	.001	3	1
UCEC	EI24 →	+0.527	+2.906	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,952 associations by consensus.

MIR4648 by TK2 expression — SKCM

Explore this box plot interactively →