TK2

Across TCGA patient cohorts, TK2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TK2-associated genes across cancer lineages are Akt_pT308, 14-3-3_beta, and A-Raf_pS299. Each is linked with TK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TK2-to-partner and partner-to-TK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by TK2-low versus TK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TK2→partner) and Y-score (partner→TK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.735	+3.321	.009	.009	3	2
UCEC	14-3-3_beta →	-0.132	-2.439	.003	.019	3	1
UCEC	A-Raf_pS299 →	-0.137	-3.169	.010	.019	3	1
UCEC	ERK2 →	+0.198	+2.000	.022	.032	3	1
UCEC	Heregulin →	-0.118	-2.986	.034	.035	3	1
UCEC	JNK2 →	+0.238	+3.026	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Akt_pT308 by TK2 expression — UCEC

Explore this box plot interactively →