TK2

Across TCGA cell cohorts, TK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,103 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TK2-associated GO terms across cancer lineages are Regulation of autophagosome assembly, Golgi to plasma membrane protein transport, and Establishment of protein localization to plasma membrane. Each is linked with TK2 in more than 11 cancer types. Because this analysis shows association rather than direction, both TK2-to-partner and partner-to-TK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of autophagosome assembly grouped by TK2-low versus TK2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TK2→partner) and Y-score (partner→TK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of autophagosome assembly →	+0.063	+0.830	.009	.001	3	12
LUNG_NSCLC_LUSC	Golgi to plasma membrane protein transport →	+0.172	+1.465	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Establishment of protein localization to plasma membrane →	+0.124	+1.211	<.001	.002	3	11
KIDNEY	Macroautophagy →	+0.060	+1.578	.001	<.001	3	11
KIDNEY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.086	+1.104	.001	.004	3	11
BONE	Positive regulation of protein binding →	+0.118	+1.038	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,103 associations by consensus.

Regulation of autophagosome assembly by TK2 expression — STOMACH

Explore this box plot interactively →