TJP3

Across TCGA cell cohorts, TJP3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TJP3-associated genes across cancer lineages are KLK12, ASCL4, and TSPAN16. Each is linked with TJP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TJP3-to-partner and partner-to-TJP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by TJP3-low versus TJP3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP3→partner) and Y-score (partner→TJP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+0.804	+4.930	<.001	.008	3	1
SOFT_TISSUE	ASCL4 →	+0.016	+4.930	<.001	.008	3	1
BLOOD_Lymphoma	TSPAN16 →	+0.043	+4.606	<.001	.001	3	1
BLOOD_Lymphoma	NLRP5 →	+0.777	+4.192	.001	.003	3	1
BLOOD_Lymphoma	KRTAP24-1 →	+0.044	+4.662	<.001	.003	3	1
SKIN	CCL25 →	+0.048	+2.832	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

KLK12 by TJP3 expression — SOFT_TISSUE

Explore this box plot interactively →