TIPRL

Across TCGA patient cohorts, TIPRL mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible TIPRL-associated genes across cancer lineages are SNORD115-20, HSFY6P, and RN7SKP295. Each is linked with TIPRL in more than 1 cancer types. Because this analysis shows association rather than direction, both TIPRL-to-partner and partner-to-TIPRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-20 grouped by TIPRL-low versus TIPRL-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPRL→partner) and Y-score (partner→TIPRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNORD115-20 →	+0.348	+7.954	<.001	.008	3	1
HNSC	HSFY6P →	+0.084	+7.954	<.001	.008	3	1
BLCA	RN7SKP295 →	+0.207	+5.899	<.001	.002	3	1
BLCA	RNU6-1174P →	+0.337	+5.497	<.001	.004	3	1
BLCA	MRPS36P3 →	+0.280	+6.018	<.001	.002	3	1
BLCA	MRPS6P4 →	+0.123	+7.040	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

SNORD115-20 by TIPRL expression — HNSC

Explore this box plot interactively →