TIPRL

Across TCGA pan-cancer cohorts, TIPRL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TIPRL data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TIPRL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIPRL expression acts as an unfavorable survival marker, although some lineages such as GBM and KIRC show a favorable association.

KIRP, ACC, and LIHC are the cancer types where TIPRL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.785	0.950	<.001	119	view →
ACC	DFS	Median	All	0.250	0.638	<.001	108	view →
LIHC	OS	Median	All	0.599	0.777	<.001	75	view →
UVM	DFS	Quartile	All	0.328	0.843	.002	74	view →
SCLC	OS	Median	All	0.430	0.711	<.001	47	view →
MESO	OS	Quartile	All	0.421	0.717	.002	41	view →
KICH	OS	Tertile	II,III,IV	0.470	0.936	.004	32	view →
PAAD	OS	Tertile	All	0.301	0.613	.003	31	view →
READ	DFS	Median	IV	0.408	0.789	.011	22	view →
BRCA	OS	Median	II,III,IV	0.890	0.933	.008	19	view →
LGG	OS	Median	All	0.761	0.902	.001	13	view →
STAD	OS	Quartile	II,III,IV	0.473	0.764	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TIPRL–KIRP (DFS)

Open the KIRP breakdown →