TIPRL

Across TCGA cell cohorts, TIPRL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,237 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIPRL-associated GO terms across cancer lineages are Regulation of endoplasmic reticulum tubular network organization, Nuclear pore complex assembly, and Positive regulation of endoplasmic reticulum tubular network organization. Each is linked with TIPRL in more than 11 cancer types. Because this analysis shows association rather than direction, both TIPRL-to-partner and partner-to-TIPRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endoplasmic reticulum tubular network organization grouped by TIPRL-low versus TIPRL-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPRL→partner) and Y-score (partner→TIPRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of endoplasmic reticulum tubular network organization →	+0.094	+0.571	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.092	+0.483	.001	.003	3	11
BLOOD_Leukemia	Positive regulation of endoplasmic reticulum tubular network organization →	+0.088	+0.551	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.087	+0.488	.001	.003	3	9
BLOOD_Lymphoma	Regulation of DNA damage checkpoint →	+0.081	+0.860	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of ATP-dependent activity →	+0.115	+0.724	.007	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,237 associations by consensus.

Regulation of endoplasmic reticulum tubular network organization by TIPRL expression — LUNG_NSCLC_LUAD

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